Enhanced anti-tumour effects of Vinca alkaloids given separately from cytostatic therapies
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چکیده
منابع مشابه
Vinca alkaloids enhance the half-life of tumour ornithine decarboxylase.
Naturally occurring vinca alkaloids, vincristine and vinblastine, at micromolar concentrations enhanced the ornithine decarboxylase activity in a dose-response manner in primary cultures of Ehrlich ascites carcinoma cells. After 8 h of culture in the presence or absence of vinblastine, cycloheximide was added to the medium, a 4.5-fold increase in the half-life of the ornithine decarboxylase act...
متن کاملVinca Alkaloids
Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant. They are naturally extracted from the pink periwinkle plant, Catharanthus roseus G. Don and have a hypoglycemic as well as cytotoxic effects. They have been used to treat diabetes, high blood pressure and have been used as disinfectants. The vinca alkaloids are also important for being cancer fighters. There ar...
متن کاملOptimized anti-tumor effects of anthracyclines plus Vinca alkaloids using a novel, mechanism-based application schedule.
Application of anthracyclines and Vinca alkaloids on the same day represents a hallmark of polychemotherapy protocols for hematopoietic malignancies. Here we show, for the first time, that both drugs might act most efficiently if they are applied on different days. Proof-of-concept studies in 18 cell lines revealed that anthracyclines inhibited cell death by Vinca alkaloids in 83% of cell lines...
متن کاملDeath and Neurological Devastation From Intrathecal Vinca Alkaloids.
Inadvertent intrathecal vincristine administration causes fatalities.
متن کاملPoisoning the spindle: serendipity and discovery of the anti-tumor properties of the Vinca alkaloids.
In 1995, Canadian scientists Robert Noble and Charles Beer were inducted into the Canadian Medical Hall of Fame for their 1950s "discovery" of Vinblastine. Their "chance" finding of an anticancer drug in the leaves of the periwinkle plant (Vinca rosea, Linn.), is used to explore the historical issue of discovery, accidental discovery, and priority. The elements of the discovery are reconstructe...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2013
ISSN: 0007-1188
DOI: 10.1111/bph.12068